Cagayan Valley ( Lambak ng Cagayan in Filipino ) is a region of the Philippines , also designated as Region II or Region 02 . It is composed of five provinces , namely: Batanes , Cagayan , Isabela , Nueva Vizcaya , and Quirino . Its regional center is Tuguegarao City .

Most of the region lies in a large valley in northeastern Luzon , between the Cordilleras and the Sierra Madre mountain ranges. Cagayan River , the country's longest river runs through its center and flows out to Luzon Strait in the north, in the town of Aparri, Cagayan . The Babuyan and Batanes island groups that lie in the Luzon Strait also belong to the region.

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